684例胆道感染患者胆汁病原菌分布及耐药性分析

目的研究胆道感染患者胆汁病原菌的分布及其耐药性,为临床合理使用抗菌药物提供依据。方法对684例胆道感染患者胆汁进行培养,应用Micro Scan Walk Away40细菌鉴定及药敏分析系统对分离菌进行鉴定及药敏测定,用WHONET 5.6软件进行数据分析。结果从684例患者胆汁中分离出315株病原菌,革兰阴性杆菌占65.1%,革兰阳性球菌占34.3%,真菌占0.6%。革兰阴性杆菌对亚胺培南、美罗培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、左氧氟沙星、头孢吡肟、庆大霉素耐药率较低。肠球菌属、葡萄球菌属对喹诺酮类耐药率较低,未发现耐万古霉素、利奈唑胺的革兰阳性球菌。结论胆道感染仍以革兰阴性杆菌为主,病原菌分布广泛,耐药情况较严重,治疗使用抗生素需要进行病原菌检测及耐药性分析。

The distribution and drug resistance of pathogenic bacteria in 684 cases of patients with biliary tract infection

Objective To investigate the distribution and drug resistance of pathogenic bacteria causing biliary tract infection,in order to provide further reference for rational use of antibacterial agents. Methods 684 cases of bile were cultured. The identification and antimicrobial susceptibility were performed by Micro Scan Walk Away40,and WHONET 5. 6 software was used to analyze the data. Results A total of 315 bacterial strains were isolated from684 cases of biliary tract infection patients. Gram-negative bacilli,Gram-positive cocci and Fungi accounted for65. 1%,34. 3% and 0. 6%,respectively. The resistance rate of Gram-negative bacilli was lower to Imipenem,Meropenem,Cefoperazone / sulbactam,Piperacillin / tazobactam,Levofloxacin,Cefepime,Gentamicin. The resistance rates of Enterococcus and Staphylococcus were lower to quinolone. No Gram-positive cocci was resistant to Vancomycin or Linezolid. Conclusion Gram-negative bacilli were main strains of biliary tract infection,antimicrobial resistance of which were serious. Biliary tract infection pathogens were widely distributed. Treatment with antibiotics needs to be based on pathogen detection and analysis of drug resistance.