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Synthesis and bioevaluation of 22-hydroxyacuminatine analogs |
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| Authors: | Grillet François Baumlová Barbora Prévost Grégoire Constant Jean-François Chaumeron Sophie Bigg Dennis C H Greene Andrew E Kanazawa Alice |
| Affiliation: | Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France. |
| Abstract: | A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity. |
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