N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents |
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| Authors: | Liang Gui-Bai Qian Xiaoxia Feng Dennis Fisher Michael Crumley Tami Darkin-Rattray Sandra J Dulski Paula M Gurnett Anne Leavitt Penny Sue Liberator Paul A Misura Andrew S Samaras Samantha Tamas Tamas Schmatz Dennis M Wyvratt Matthew Biftu Tesfaye |
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| Affiliation: | Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. gui-bai_liang@merck.com |
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| Abstract: | Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved. |
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