Isolation and the fluorometric, high-performance liquid chromatographic determination of tacrine |
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| Authors: | T H Park K H Tachiki W K Summers D Kling J Fitten K Perryman K Spidell A S Kling |
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| Institution: | 1. Psychiatry Service and Chief of Staff, Veterans Administration Medical Center, Sepulveda, California 91343, USA;2. Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles, California 90024 USA;1. National Alzheimer''s Coordinating Center, University of Washington, 4311 11th Ave NE, Suite 300, Seattle, WA, 98105, USA;2. University of California San Diego, Department of Neurosciences, National Parkinson Foundation Movement Disorder Center of Excellence, 8950 Villa La Jolla Drive, Suite C112, La Jolla, CA, 92037, USA;3. Cognitive Neurology and Alzheimer''s Disease Center, and Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 320 E Superior, Searle 11-467, Chicago, IL, 60611, USA;1. Department of Obstetrics and Gynecology, Hospital Universitari i Politècnic La Fe, Valencia, Spain;2. Department of Gynecology, Hospital Universitario Bellvitge-Idibell, Barcelona, Spain;3. Department of Microbiology, Hospital Universitari i Politècnic La Fe, Valencia, Spain;4. Department of Pediatrics, Hospital Universitari i Politècnic La Fe, Valencia, Spain;5. Facultad Medicina, Departamento Pediatría Obstetricia y Ginecología, Universidad Valencia, Spain;1. Northeast Ohio Medical University, Rootstown, OH, USA;2. The Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;3. School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;4. Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;5. Department of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;1. University of Miami, Miller School of Medicine, Miami, FL, USA;2. Wayne State University, Detroit, MI, USA;3. University of California San Diego, San Diego, CA, USA;4. Harvard Medical School, Boston, MA, USA;5. University of North Carolina, Chapel Hill, NC, USA;6. University of Illinois College of Medicine, Chicago, IL, USA;7. San Diego State University, San Diego, CA, USA;8. Albert Einstein College of Medicine, Bronx, NY, USA;9. Feinberg School of Medicine, Chicago, IL, USA;1. Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA;2. Adult & Gerontological Health Co-Operative, School of Nursing, University of Minnesota, Minneapolis, MN, USA;3. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA |
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| Abstract: | Tacrine (THA; 1,2,3,4-tetrahydro-9-aminoacridine) is an anticholinesterase agent which has been used clinically, most recently in the treatment of Alzheimer-type dementias. This paper describes the methodology for the isolation and quantitation of THA at therapeutic levels in serum from human subjects. Using C18 Bond Elut columns and an HPLC/fluorometry system, this assay exhibits a considerable improvement in sensitivity over previous uv methods, and allows routine testing of THA levels in serum samples of reasonable volume from human subjects. |
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