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Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning
Authors:Jiao Jianwei  Nakajima Akira  Janssen William G M  Bindokas Vytautas P  Xiong Xiaoli  Morrison John H  Brorson James R  Tang Ya-Ping
Institution:Department of Psychiatry, University of Chicago, Chicago, Illinois, USA.
Abstract:It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills, which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice. These results indicate that changes in the expression of gene(s) that are involved in regulating synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.
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