X-ray microanalysis of cAMP-induced ion transport in cystic fibrosis fibroblasts. |
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| Authors: | A von Euler G M Roomans |
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| Institution: | Department of Human Anatomy, University of Uppsala, Sweden. |
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| Abstract: | cAMP-induced ion transport in normal and cystic fibrosis (CF) fibroblasts was investigated by X-ray microanalysis. Stimulation with cAMP causes an increase in cellular Na content and a decrease in cellular Cl and K content. No significant difference in response between CF and normal cells was noted. In this respect, fibroblasts differ from epithelial cells, where cAMP-induced Cl- efflux blocked in CF patients. Isoproterenol produced similar changes in Na and K content as cAMP, but did not effect Cl content. |
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