Clinical Utility of Antithrombotic Prophylaxis in ART Procedures: An Italian Experience |
| |
| Authors: | Elvira Grandone Michela Villani Giovanni L. Tiscia Francesco Dentali Donatella Colaizzo Filomena Cappucci Lucia Fischetti Walter Ageno Maurizio Margaglione |
| |
| Affiliation: | 1. Atherosclerosis and Thrombosis Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Foggia, Italy.; 2. Department of Clinical Medicine, Insubria University, Varese, Italy.; 3. Medical Genetics, University of Foggia, Foggia, Italy.; Medical Faculty, Otto-von-Guericke University Magdeburg, Medical Faculty, Germany, |
| |
| Abstract: | BackgroundThe usefulness of antithrombotic prophylaxis in management of Assisted Reproductive Technologies (ART) is questionable.ObjectivesWe prospectively examined the contribution of an antithrombotic prophylaxis in influencing clinical pregnancy and live-birth in an unselected cohort of women approaching ART.Patients/Methods1107 women with fertility problems and a valid indication for ART were recruited. Baseline and follow-up information of obstetric outcomes and antithrombotic treatment were collected.Results and ConclusionsMedian follow-up time was 34.5 months (range: 2–143). During the follow-up period, 595 (53.8%) women underwent ART (total 1234 cycles); 202 (33.9%) women achieved a pregnancy for a total of 255 clinical pregnancies. The concomitant use of LMWH and aspirin was significantly associated with a higher rate of clinical pregnancies (p: 0.003, OR: 4.9, 95% CI: 1.7–14.2). The pregnancy rate was also significantly increased by the use of LMWH alone (p: 0.005, OR: 2.6, 95% CI: 1.3–5.0). Carriership of inherited or acquired thrombophilia did not affect clinical outcomes of the ART. The efficacy of antithrombotic treatment was confirmed when the outcome “ live-birth” was considered. Present data suggest a potential benefit of antithrombotic prophylaxis during ART in improving the number of live-births. |
| |
| Keywords: | |
|
|
