Semantic integration to identify overlapping functional modules in protein interaction networks |
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Authors: | Young-Rae Cho Woochang Hwang Murali Ramanathan Aidong Zhang |
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Affiliation: | (1) Department of Computer Science and Engineering, State University of New York, Buffalo, NY, USA;(2) Department of Pharmaceutical Science, State University of New York, Buffalo, NY, USA |
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Abstract: | Background The systematic analysis of protein-protein interactions can enable a better understanding of cellular organization, processes and functions. Functional modules can be identified from the protein interaction networks derived from experimental data sets. However, these analyses are challenging because of the presence of unreliable interactions and the complex connectivity of the network. The integration of protein-protein interactions with the data from other sources can be leveraged for improving the effectiveness of functional module detection algorithms. |
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