Enhancement of histamine synthesis in mouse skin by epinephrine |
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| Authors: | A M Rothschild |
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| Affiliation: | Department of Pharmacology, School of Medicine of Ribeirão Preto, USP, Ribeirão Preto, 14.100, SP, Brazil |
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| Abstract: | Intravenous administration of 10-40 micrograms/Kg epinephrine to mice leads to a transient 50% increase in skin histamine, followed by an increase in blood histamine. Delayed inhibition by alpha-fluorometyl histidine (alpha FMH), suggests that these changes follow stimulation of pre-formed tissue histidine decarboxylase. |
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