Interaction of wheat germ ca-dependent protein kinases with calmodulin antagonists and polyamines |
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Authors: | Polya G M Micucci V |
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Institution: | Department of Biochemistry, La Trobe University, Bundoora, Victoria, 3083, Australia. |
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Abstract: | The two soluble Ca2+-dependent protein kinases resolved from wheat (Triticum aestivum) embryo (protein kinases I and II) are inhibited by the phenothiazine-derived calmodulin antagonists trifluoperazine fluphenazine, and chlorpromazine. Protein kinases I and II are also inhibited by a variety of other calmodulin antagonists (including calmidazolium, amitriptyline, and iprindole), phosphodiesterase inhibitors (including flufenamic acid and papavarine) and by lanthanides. A number of compounds that inhibit mammalian Ca2+ - and phospholipid-activated protein kinase (protein kinase C) including quercetin, polymixin B sulfate, and polyamines (as well as phenothiazine derivatives) also inhibit protein kinases I and II. Poly-l-lysine and poly-l-ornithine activate both plant Ca2+-dependent protein kinases. |
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