MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II |
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| Authors: | Jian Xiao Xiaoyan Zhu Bin He Yufeng Zhang Bo Kang Zhinong Wang Xin Ni |
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| Affiliation: | (1) Department of Cardiothoracic Surgery, Changzheng Hospital, the second military medical university, Fengyang road 415#, shanghai, 200003, China;(2) Department of Physiology, the second military medical university, Xiangyin road 800#, Shanghai, 200433, China;(3) Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang road 1665#, Shanghai, 200092, China |
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| Abstract: | Background Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to protect cardiomyocytes against apoptosis during IR, while whether it has anti-autophagy effect has not been known. The aim of this study was to investigate whether miR-204 regulated autophagy by regulating LC3-II protein, which is the marker of autophagosome during myocardial IR injury. |
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