Enzymatic synthesis of 2-amino- 3-hydroxy-1,6-hexanedicar☐ylic acid using serinehydroxymethyltransferase |
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Authors: | M.J. Miller S.K. Richardson |
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Affiliation: | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA |
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Abstract: | The scale up of earlier work from these laboratories using the enzyme serinehydroxymethyltransferase has resulted in the use of this enzyme for the synthesis of 2-amino-3-hydroxy-1,6-hexanedicar☐ylic acid (7) on a preparative scale. This compound, which has been barely described in the literature, is potentially useful for the synthesis of carbocyclic β-lactams and carbocyclic nucleosides. |
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Keywords: | Serinehydroxymethyltransferase Amino acids Aldol reaction β-Lactams |
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