The role of LAIR-1 (CD305) in T cells and monocytes/macrophages in patients with rheumatoid arthritis |
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Authors: | Y Zhang K Lv CM Zhang BQ Jin R Zhuang Y Ding |
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Institution: | 1. Department of Physiology, Fourth Military Medical University, #17 Changle West Road, Xi’an 710032, China;2. Department of Orthopedic, The Second Affiliated Hospital, Xi’an Jiaotong University College of Medicine, #157 Xiwu Road, Xi’an 710003, China;3. Department of Immunology, Fourth Military Medical University, #17 Changle West Road, Xi’an 710032, China;4. Department of Orthopedic, Tangdu Hospital, Fourth Military Medical University, #1 Xinsi Road, Xi’an 710038, China |
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Abstract: | The LAIR-1 receptor is expressed on a majority of mononuclear leukocytes. It is used as a biomarker when testing synovial fluid for evidence of rheumatoid arthritis (RA). The primary objective of this study was to measure T cell- and monocyte/macrophage-specific LAIR-1 expression in RA patients and compare this to LAIR-1 expression in osteoarthritis (OA) patients and healthy individuals. LAIR-1 expression was significantly decreased in circulating CD4+ T cells in RA patients compared to both OA patients and healthy individuals. In contrast, LAIR-1 is high in CD14+ monocytes and local CD68+ macrophages in synovial tissues from RA patients. Upon stimulation with TNF-α, LAIR-1 expression decreased in T-helper (Th)1 and Th2 CD4+ T cells from healthy donors. These results indicate that LAIR-1 may exert different functions on T cells and monocytes/macrophages and suggest that LAIR-1 may be a novel therapeutic target for the treatment of RA. |
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Keywords: | LAIR-1 T cells Monocytes/macrophages Rheumatoid arthritis |
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