A New Cytotoxic Oxyneolignan from the Roots andStems of Clausena lansium (Rutaceae)* |
| |
| Authors: | SONG Wei-Wu ZENG An-Zhi PENG Wen-Wen TAN Ning-Hua |
| |
| Institution: | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy ;
of Sciences, Kunming 650201, China;2.University of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | A new oxyneolignan, claulignan (1), together with seven known compounds (2-8), were isolated from the methanol extract of the roots and stems of Clausena lansium. Their structures were elucidated on the basis of 1D and 2D NMR experiments and mass spectrometry. Compounds 2-8 were isolated from the genus Clausena for the first time. Compounds 1 and 6 showed cytotoxicity against human cervical cancer HeLa cell line with the IC50values of 2503 and 5399μM, respectively. Compound 3 exhibited antioxidant activity in the DPPH assay with the EC50 value of 26896g·kg-1. |
| |
| Keywords: | Clausena lansium Oxyneolignan Cytotoxicity DPPH Claulignan |
|
| 点击此处可从《Plant Diversity》浏览原始摘要信息 |
| 点击此处可从《Plant Diversity》下载免费的PDF全文 |
