Filamin: A Structural and Functional Biomolecule with Important Roles in Cell Biology,Signaling and Mechanics |
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| Authors: | Hassan P Modarres Mohammad R K Mofrad |
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| Institution: | ∗
Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering,
University of California, Berkeley, CA 94720.†
Corresponding Author. Department of Bioengineering, University of California Berkeley, 208A
Stanley Hall #1762, Berkeley, CA 94720-1762. Phone: (510) 643-8165; Fax: (510) 642-5835;
Email: mofrad@berkeley.edu |
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| Abstract: | Focal adhesions are the immediate sites of the cell’s adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin’s protein-protein interaction network in cell mechanobiology. |
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