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Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization |
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| Authors: | Emmanuel G Reynaud Miguel A Andrade Fabien Bonneau Thi Bach Nga Ly Michael Knop Klaus Scheffzek and Rainer Pepperkok |
| Institution: | (1) Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany;(2) Ontario Genomics Innovation Centre, Ottawa Health Research Institute, 501 Smyth, Ottawa, ON, K1H 8L6, Canada;(3) Structural and Computational Programme, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany |
| Abstract: | BackgroundCompartmentalization is a key feature of eukaryotic cells, but its evolution remains poorly understood. GTPases are the oldest enzymes that use nucleotides as substrates and they participate in a wide range of cellular processes. Therefore, they are ideal tools for comparative genomic studies aimed at understanding how aspects of biological complexity such as cellular compartmentalization evolved. |
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