Effects of thrombin,PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro |
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| Authors: | Aonghus?J?O'Loughlin Crochan?J?O'Sullivan Nandini?Ravikumar Anne?M?Friel John?T?Elliott Email author" target="_blank">John?J?MorrisonEmail author |
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| Institution: | (1) Dept. of Obstetrics & Gynaecology, National University of Ireland Galway, Clinical Science Institute, University College Hospital Galway, Newcastle Road, Galway, Ireland;(2) Biotechnology Division/Biomaterials Group, NIST, 100 Bureau Dr. Bldg 227 Rm A249, 20899-8313 Gaithersburg, MD, USA |
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| Abstract: | Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs),
and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of
thrombin, a specific PAR-1 activating peptide (PAR1-AP), and a PAR-1 antagonist on human umbilical artery tone in vitro. |
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