Sequence variation in ligand binding sites in proteins期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Sequence variation in ligand binding sites in proteins

Authors:	Thomas?J?Magliery author-information" > author-information__contact u-icon-before" > mailto:magliery@chemistry.ohio-state.edu" title=" magliery@chemistry.ohio-state.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Lynne?Regan author-information" > author-information__contact u-icon-before" > mailto:lynne.regan@yale.edu" title=" lynne.regan@yale.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Molecular Biophysics & Biochemistry, Yale University, P.O. Box 208114, New Haven, CT 06520-8114, USA;(2) Present address: Department of Chemistry and Department of Biochemistry, The Ohio State University, 100 W. 18th Ave, Columbus, OH 43210, USA;(3) Department of Chemistry, Yale University, New Haven, CT, USA

Abstract:	Background The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of these proteins can be structurally or functionally categorized from sequence conservation alone. In contrast, little attention has been given to the meaning of poorly-conserved sites in families of proteins, which are typically assumed to be of little structural or functional importance.

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