Phlorotannins as Radical Scavengers from the Extract of Sargassum ringgoldianum |
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Authors: | Masaaki Nakai Norihiko Kageyama Koichi Nakahara Wataru Miki |
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Institution: | (1) Suntory Research Center, Suntory, Ltd., Wakayamadai 1-1-1, Shimamoto-cho, Mishima-gun Osaka, 618-8503, Japan |
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Abstract: | To screen algal phlorotannins with antioxidative activities, 50% ethanol extracts of 25 Japanese marine algae were evaluated.
Scavenging activity against superoxide anion radicals was frequently found with a high content of total phenolic compounds.
Among these, the extract from the brown seaweed, Sargassum ringgoldianum, showed the strongest scavenging activity. The active fraction contained a mixture of high molecular weight polyphenols,
phlorotannins that were found to be polymerized bifuhalol, as analyzed by matrix-assisted laser desorption/ionization time-of-flight
mass spectrometry (MALDI-TOF MS). The scavenging activity of the fraction against superoxide anion radicals was estimated
to be 1.0 μg/ml (IC50), which were approximately five times stronger than that of catechin. |
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Keywords: | Bifuhalol Phlorotannin Radical scavenger Sargassum ringgoldianum |
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