A chemically-defined medium supporting growth and providing cells converting compactin to pravastatin |
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| Authors: | Y Peng E A Walker J C Davis A L Demain |
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| Affiliation: | (1) Fermentation Microbiology Laboratory, Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, US |
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| Abstract: | Actinomadura sp strain 2966, which converts compactin to pravastatin, requires vitamins to support its growth. Addition of folic acid, thiamine and cyanocobalamine allowed growth in chemically-defined medium. Cells grown in a chemically-defined medium were as capable of converting compactin to pravastatin as cells grown in a complex medium. Received 9 October 1998/ Accepted in revised form 20 December 1998 |
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| Keywords: | : Actinomadura pravastatin compactin nutrition vitamins |
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