Cell death in hematological tumors |
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Authors: | Simone Fulda |
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Institution: | (1) University Children’s Hospital, Eythstr.24, 89075 Ulm, Germany |
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Abstract: | Evasion of apoptosis is a hallmark of human cancers, for example in hematological malignancies. Apoptosis is an intrinsic
cell death program that is crucial to maintain tissue homeostasis, for example in the hematopoietic system where there is
a high turnover rate of cells. As a result, a decrease in the rate of apoptosis besides an increase in proliferation favors
tumorigenesis as well as tumor progression. Further, the anti-leukemic action of current treatment approaches, including chemo-,
radio- or immunotherapy, critically relies on intact cell death programs in cancer cells. Therefore, defects in apoptosis
pathways are frequently associated with the resistance to anticancer therapies. In recent years, the identification and characterization
of the molecules and pathways that are involved in the regulation and execution of cell death in leukemia and lymphoma cells
have set the ground for the development of novel diagnostic tools and molecular therapeutics targeting apoptosis pathways
in hematological malignancies. |
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Keywords: | Apoptosis Leukemia Lymphoma TRAIL IAPs Bcl-2 |
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