|
|||||
|
|
Micronucleus frequency and content in healthy relatives of cancer patients |
|
| Authors: | Friedo Zölzer Marcela Křížová Zuzana Freitinger Skalická Andrea Rössnerová Radim Šrám |
| Affiliation: | 1. Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Sciences, University of South Bohemia, ?eské Budějovice, Czech Republic;2. Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic |
| Abstract: | Objective: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer. Materials and methods: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei. Results: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n.s.) and the proportion of centromere-free micronuclei (p? Conclusion: The chromosomal damage observed may be due to inheritable genomic instability, but environmental influences cannot be excluded. |
| Keywords: | Micronucleus centromere test chromosomal damage inheritable trait cancer predisposition radon chromosomal damage inheritable trait cancer predisposition radon |