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Elevated serum YKL-40 levels in patients with Kawasaki disease |
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| Authors: | K Y Kim Y Ahn D Y Kim Ho-Seong Kim |
| Institution: | 1. Department of Pediatrics, Yonsei University College of Medicine, Severance Children’s Hospital, Seoul, South Korea;2. Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea |
| Abstract: | Context: YKL-40 is an inflammatory biomarker for endothelial dysfunction that may have a role in Kawasaki disease (KD). Objectives: We investigated the association of serum YKL-40 levels with KD and established laboratory parameters for YKL-40 levels and other inflammatory markers. Methods: YKL-40 levels and other inflammatory markers of 23 KD patients, 9 disease control patients and 11 age-matched healthy controls. Results: YKL-40 concentration in the serum of KD patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls. Conclusions: Increased YKL-40 levels may provide a useful inflammatory marker for patients with KD. |
| Keywords: | Kawasaki disease acute phase reactant YKL-40 |