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High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study |
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| Authors: | Richard Nowak Christian Mueller Evangelos Giannitsis Michael Christ Jordi Ordonez-Llanos Christopher DeFilippi |
| Institution: | 1. Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA;2. Department of Cardiology &3. Cardiovascular Research Institute Basel, University Hospital Base, Basel, Switzerland;4. Department of Internal Medicine, Cardiology, Angiology &5. Pulmonary, University Hospital Heidelberg, Heidelberg, Germany;6. Department of Emergency and Critical Care Medicine, Paracelsus Medical University, Germany, Nuernberg;7. Biochemistry, Hospital de Sant Pau, Barcelona, UK;8. Cardiology, University of Maryland, Baltimore, MD, USA |
| Abstract: | Purpose: To describe the baseline, 1?hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis. Materials and methods: hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin. The baseline, 1?hr and delta hs-cTnT values were analysed in the 902 non-ACS patients. Results: Amongst the 1282 studied the patient groups were 213 (17%) AMI, 167 (13%) unstable angina, 113 (9%) non-ACS cardiac, 288 (22%) non-cardiac and 501 (39%) unknown origin. The hs-cTnT values in the non-cardiac and unknown origin groups were combined. The median hs-cTnT values (ng/L) were higher (p?<?0.001) in the non-ACS cardiac compared to the non-cardiac/unknown origin group at baseline (11.8,?<5) and 1?hr (12.3,?<5). Their negative predictive values were 0.955 (baseline) and 0.954 (1?hr) for predicting non-ACS cardiac versus non-cardiac/unknown origin diagnoses. Conclusions: Hs-cTnT may help predict whether non-ACS ED patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses. |
| Keywords: | High sensitivity troponin non ACS patients emergency department |