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Serum uromodulin predicts graft failure in renal transplant recipients |
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| Authors: | Dominik Steubl Matthias Block Victor Herbst Wolfgang Schlumberger Andreas Nockher Susanne Angermann |
| Affiliation: | 1. Department of Nephrology, Klinikum rechts der Isar, Technische Universit?t, München, Germany;2. Research&3. Development Department, Euroimmun Medizinische Labordiagnostika AG, Lübeck, Germany;4. Institute of Laboratory Medicine and Pathobiochemistry, Universit?tsklinikum Marburg, Philipps-Universit?t Marburg, Marburg, Germany |
| Abstract: | Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0?ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration. |
| Keywords: | Biomarker uromodulin Tamm–Horsfall protein kidney transplantation graft failure proteinuria eGFR cystatin C |