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Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer |
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| Authors: | Selma Gogalic Ursula Sauer Sara Doppler Andreas Heinzel Paul Perco Arno Lukas |
| Institution: | 1. Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH, Tulln, Austria;2. Emergentec Biodevelopment GmbH, Vienna, Austria |
| Abstract: | Context: About 50–70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease. Objective: To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC. Materials and methods: Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis. Results: A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96. Discussion and conclusion: This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC. |
| Keywords: | Recurrent bladder cancer ECadh IL8 MMP9 EN2 VEGF |