| 维持胚胎干细胞自我更新状态的分子信号途径 |
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| 引用本文： | 高远,宋后燕.维持胚胎干细胞自我更新状态的分子信号途径[J].细胞生物学杂志,2005,27(4):379-382. |
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| 作者姓名： | 高远 宋后燕 |
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| 作者单位： | 复旦大学分子医学教育部重点实验室、复旦大学生物医学研究院干细胞与组织工程研究所,上海200032 |
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| 摘 要： | 胚胎干细胞是从胚胎植入前期胚泡内细胞团分离的细胞，可以长久维持对称性自我更新的未分化状态。多种胞内外细胞因子介导的信号途径参与这种状态的调节。现对胚胎干细胞自我更新途径分子机制进行综述，并提出有待进一步阐明的相关问题。
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| 关 键 词： | 胚胎干细胞 自我更新 分子信号途径 信号途径 分子机制 状态 内细胞团 胚胎植入 细胞因子 对称性 |
| 收稿时间： | 2005-03-15 |
| 修稿时间： | 2005-04-27 |
Molecular Signaling Pathway for Maintaining Self-renewal of Embryonic Stem Cells |
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| Gao Yuan;Song HouYan.Molecular Signaling Pathway for Maintaining Self-renewal of Embryonic Stem Cells[J].Chinese Journal of Cell Biology,2005,27(4):379-382. |
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| Authors: | Gao Yuan;Song HouYan |
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| Abstract: | Embryonic stem cells (ES cells) are derived from the inner cell mass (ICM) of mammalianpreimplantation blastocyte. They can undergo symmetrically self-renew to consistently maintain the undifferentiatedstate. Multiple cytokine-mediated signaling pathways participate in regulating such status of ES cells. We reviewedthe molecular signaling pathways being critical to the maintenance of self-renewal of ES cells based on the currentresearch results. And furthermore, we addressed some pending results which seem to be essential for the undiffer-entiated proliferation of ES cells. |
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| Keywords: | embryonic stem cell self-renewal molecular signaling pathway |
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