Influence of the Geometry of an Axo-Dendritic Synapse and Its Position on the Dendrite on the Current Recorded from the Neuronal Soma

Using mathematical simulation,we studied the influence of the geometry of an axo-dendritic synapse and its position on the dendrite on the value of the postsynaptic current that arrives at the soma. It was shown that the geometric dimensions of the synaptic cleft and the conductance of postsynaptic receptor-channel complexes determine the value of the current coming into the postsynaptic cell, while the geometry and conductance of the dendrite determine the part of this current arriving at the soma. At a constant conductance of the postsynaptic membrane but with an increase in the diameter of the synaptic contact and a decrease in the width of the synaptic cleft, the current coming into the postsynaptic unit decreases, but the reversal potential for this current under these conditions does not change. Vice versa, influences determined by changes in the geometry and ion conductance of the dendrite membrane are capable not only of decreasing the current injected into the soma but also of changing its reversal potential. The thinner the dendrite and the more distant the location of the synapse from the soma, the more significant such effects. Neirofiziologiya/Neurophysiology, Vol. 37, No. 2, pp. 101–107, March–April, 2005.