Regional distribution of catecholamines in rat brain after L-3-O-methyldopa and L-dopa |
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Authors: | G Bartholini K G Lloyd A Pletscher |
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Institution: | Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd, Basel, Switzerland |
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Abstract: | The distribution of labelled dopamine (DA) and noradrenaline (NA) in the various brain regions of the rat was similar after administration of L-14C-3-0-methyldopa (OMD) or L-14C-dopa, DA showing the greatest accumulation in the striatum and NA in the hypothalamus. The concentration of catecholamines 2 hours after OMD amounted to 2–15 % of those found after L-dopa. In the whole brain, the cerebral catecholamines formed from dopa decreased more rapidly than those originating from OMD. In conclusion, OMD is a precursor of cerebral catecholamines; however, it is less effective than dopa. |
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