Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals |
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| Authors: | Melissa S Hillwig Ludmila Rizhsky Ying Wang Alisa Umanskaya Jeffrey J Essner Gustavo C MacIntosh |
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| Institution: | (1) Interdepartmental Genetics Graduate Program, Iowa State University, Ames, IA 50011, USA;(2) Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA;(3) Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA |
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| Abstract: | Background Members of the Ribonuclease (RNase) T2 family are common models for enzymological studies, and their evolution has been well
characterized in plants. This family of acidic RNases is widespread, with members in almost all organisms including plants,
animals, fungi, bacteria and even some viruses. While several biological functions have been proposed for these enzymes in
plants, their role in animals is unknown. Interestingly, in vertebrates most of the biological roles of plant RNase T2 proteins
are carried out by members of a different family, RNase A. Still, RNase T2 proteins are conserved in these animals |
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