Production and characterization of recombinant pertactin, fimbriae 2 and fimbriae 3 from Bordetella pertussis |
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| Authors: | Yinghua Xu Yaying Wang Yajun Tan Huajie Zhang Lijie Wu Lichan Wang Qiming Hou Shumin Zhang |
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| Institution: | (1) Department of serum, National Institute for the Control of Pharmaceutical and Biological Products, Temple of Heaven, 100050 Beijing, PR China |
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| Abstract: | Background
Bordetella pertussis is a causative agent of pertussis or whooping cough in humans. Pertactin (Prn), fimbriae 2 (Fim2) and fimbriae 3 (Fim3) of
B. pertussis are important virulence factors and immunogens which have been included in some acellular pertussis vaccines. In this present
study, we cloned, expressed and purified Prn, Fim2 and Fim3, respectively. The immunogeniCity and protective efficacy of the
three recombinant proteins (rPrn, rFim2 and rFim3) were investigated in mouse model. |
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