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Association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility: a meta-analysis |
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| Authors: | Jianbing Hu Chuan Liu Qinghua Yin Mingzhen Ying Junhui Li Lian Li Chun-xia Zhou Yajie Wang |
| Affiliation: | 1. Department of Oncology, The First People’s Hospital of Yueyang, Yueyang, People’s Republic of China 2. Department of Oncology, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China 3. Yueyang Second People’s Hospital, Yueyang, People’s Republic of China 4. Department of Gynaecology and Obstetrics, Danyang Second People’s Hospital, Danyang, JiangSu province, People’s Republic of China 5. Economic Development Zone, 33 Jiuqu Road, Danyang, 212300, JiangSu province, People’s Republic of China |
| Abstract: | To date, epidemiological studies have assessed the association between CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. However, the results of these studies remained controversial. We aimed to examine the associations by conducting a meta-analysis of case–control studies. A total of 11 studies including 5,093 cases and 5,941 controls evaluated the association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. No significantly associations were found in all genetic models (CC vs. AA: OR = 1.14, 95 % CI = 0.93–1.40; AC vs. AA: OR = 1.05, 95 % CI = 0.91–1.20; dominant model: OR = 1.08, 95 % CI = 0.95–1.24; recessive model: OR = 1.10, 95 % CI = 0.95–1.28). In the subgroup analysis by ethnicity or source of controls, there were still no significant associations detected in all genetic models. This meta-analysis suggested the CYP1A2-164 A/C polymorphism was not a risk factor for increasing colorectal cancer, further large and well-designed studies are needed to confirm these conclusions. |
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