Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase. |
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| Authors: | M Grompe M al-Dhalimy |
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| Institution: | Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201. |
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| Abstract: | Hereditary tyrosinemia type I is caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH) (EC 3.7.1.2), the final step in tyrosine degradation. We report here the cloning and sequencing of a full length cDNA coding for murine FAH. This cDNA is highly homologous to the previously cloned human and rat genes. |
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