1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists |
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| Authors: | Bakshi Raman K Hong Qingmei Olson J T Ye Zhixiong Sebhat Iyassue K Weinberg David H MacNeil Tanya Kalyani Rubana N Tang Rui Martin William J Strack Alison McGowan Erin Tamvakopoulos Constantin Miller Randy R Stearns Ralph A Tang Wei Maclntyre D Euan van der Ploeg Lex H T Patchett Arthur A Nargund Ravi P |
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| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com |
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| Abstract: | The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described. |
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