硫化氢在肾脏病中的保护作用

肾脏病发病率逐年增高,已经成为影响人类健康的重要疾病之一。硫化氢是继NO、CO之后的第三种气体信号分子,大剂量有毒害作用,但生理浓度的硫化氢起到舒张血管、抗氧化、抗炎、抗凋亡等重要作用。肾脏病尤其继发性肾脏病如梗阻性肾病、肾移植、糖尿病肾病及高血压性肾损害等与血管病变、氧化应激、炎症密切相关,那么硫化氢与肾脏疾病之间有怎样的关系,本文将就硫化氢在肾脏病中的保护作用做一综述。

Protective Effect of Hydrogen Sulfide in the Secondary Renal Disease and Renal Transplantation

The prevalence of kidney disease was increasing,which has become an important threaten to the health of the population.Hydrogen sulfide is the third gas signaling molecules after CO and NO.It has toxic effect at high concentration,but plays an important role in relaxing blood vessel ,antioxidation anti -inflammation and anti-apoptosis at physiological concentration.Kidney disease,especially seconda-ry kidney disease such as obstructive nephropathy,renal transplantation,diabetic nephropathy and hyper-tensive kidney lesion are closely related to vascular leision,oxidative stress and inflammation.Then what's the relationship between hydrogen sulfide and kidney disease?This article will review the relationship between hydrogen sulfide and kidney disease.