| 单胺氧化酶 |
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| 引用本文： | 陈剑峰,王恩多.单胺氧化酶[J].生物化学与生物物理进展,2000,27(5):504-508. |
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| 作者姓名： | 陈剑峰 王恩多 |
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| 作者单位： | 中国科学院上海生物化学研究所,分子生物学国家重点实验室,上海,200031 |
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| 摘 要： | 单胺氧化酶（monoamine oxidase,MAO）是生物体内一种十分重要的酶，它在大脑和周围神经组织中催化一些生物体产生的胺，氧化脱氨产生过氧化氢（H2O2）.单胺氧化酶A和B基因的克隆清楚地证明了这些酶是由不同的多肽组成的.单胺氧化酶A和B的基因定位于X染色体（Xp11.23），都由15个外显子组成，而且它们的内含子-外显子组织是完全一致的.这些事实表明单胺氧化酶A和B的基因很可能从同一个祖先进化而来.单胺氧化酶A和B具有不同的底物和抑制剂专一性，在生物神经递质代谢和行为方面具有不同的作用.
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| 关 键 词： | 单胺氧化酶，神经递质，行为 |
| 收稿时间： | 1999/10/14 0:00:00 |
| 修稿时间： | 2000/2/24 0:00:00 |
Monoamine Oxidase |
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| CHEN Jian-Feng and WANG En-Duo.Monoamine Oxidase[J].Progress In Biochemistry and Biophysics,2000,27(5):504-508. |
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| Authors: | CHEN Jian-Feng and WANG En-Duo |
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| Institution: | State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China;State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | Monoamine oxidase (MAO) catalyzes the oxidative deamination of a number of biogenic amines in the brain and peripheral tissues by the production of hydrogen peroxide(H2O2). The cloning of MAO A and B genes has demonstrated that the enzymes are made of different polypeptides. MAO A and B genes are located on the X-chromosome (Xp11.23) and consist of 15 exons with identical intron-exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B exhibit distinct differences in the substrate selectivity and inhibitor sensitivity and play different role in the neurotrasmitter metabolism and behavior. |
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| Keywords: | monoamine oxidase neurotrasmitter behavior |
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