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Molecular strategies to replace the structural metal site in the prokaryotic zinc finger domain |
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| Authors: | Ilaria Baglivo Maddalena Palmieri Alessia Rivellino Fortuna Netti Luigi Russo Sabrina Esposito Rosa Iacovino Biancamaria Farina Carla Isernia Roberto Fattorusso Paolo Vincenzo Pedone Gaetano Malgieri |
| Affiliation: | 1. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Via Vivaldi 43, 81100 Caserta, Italy;2. Interuniversity Centre for Research on Bioactive Peptides (CIRPEB), University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy;3. Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, 80134 Naples, Italy |
| Abstract: | The specific arrangement of secondary elements in a local motif often totally relies on the formation of coordination bonds between metal ions and protein ligands. This is typified by the ~ 30 amino acid eukaryotic zinc finger motif in which a β-sheet and an α-helix are clustered around a zinc ion by various combinations of four ligands. |
| Keywords: | Prokaryotic zinc finger Thermal unfolding DNA binding |
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