High fat diet aggravates cardiomyopathy in murine chronic Chagas disease |
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Authors: | Kezia Lizardo Janeesh Plakkal Ayyappan Min-Hui Cui Rashmi Balasubramanya Linda A Jelicks Jyothi F Nagajyothi |
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Institution: | 1. Department of Microbiology, Biochemistry and Molecular Genetics, Public Health Research Institute, New Jersey Medical School, Newark, USA;2. Department of Radiology, Albert Einstein College of Medicine, 1300, Morris Park Avenue, Bronx, NY, USA;3. Department of Medicine, Albert Einstein College of Medicine, 1300, Morris Park Avenue, Bronx, NY, USA;4. Department of Radiology, Mercy Medical Center, Springfield, MA, USA |
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Abstract: | Infection with Trypanosoma cruzi, the etiologic agent in Chagas disease, may result in heart disease. Over the last decades, Chagas disease endemic areas in Latin America have seen a dietary transition from the traditional regional diet to a Western style, fat rich diet. Previously, we demonstrated that during acute infection high fat diet (HFD) protects mice from the consequences of infection-induced myocardial damage through effects on adipogenesis in adipose tissue and reduced cardiac lipidopathy. However, the effect of HFD on the subsequent stages of infection – the indeterminate and chronic stages – has not been investigated. To address this gap in knowledge, we studied the effect of HFD during indeterminate and chronic stages of Chagas disease in the mouse model. We report, for the first time, the effect of HFD on myocardial inflammation, vasculopathy, and other types of dysfunction observed during chronic T. cruzi infection. Our results show that HFD perturbs lipid metabolism and induces oxidative stress to exacerbate late chronic Chagas disease cardiac pathology. |
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Keywords: | Chagasic cardiomyopathy High fat diet Lipid metabolism Mitochondrial dysfunction RAGE Inflammation |
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