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Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants
Authors:Weimin Zhang  Xuedi Zhang  Zhaoyu Xue  Yijie Li  Qing Ma  Xiangle Ren  Jiaying Zhang  Songhua Yang  Lijuan Yang  Menghua Wu  Mengda Ren  Rongwen Xi  Zheng Wu  Ji-Long Liu  Erika Matunis  Junbiao Dai  Guanjun Gao
Affiliation:1. School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, PR China;2. Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, PR China;3. Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA;4. National Institute of Biological Sciences, Beijing 102206, PR China;5. Shenzhen Key Laboratory of Synthetic Genomics and Center for Synthetic Genomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China
Abstract:
Keywords:CRISPR/Cas9  FLP-FRT  dosage effects  histone mutant library  H4K16  mosaic system
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