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The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
Authors:Davide D’Amico  Adrienne Mottis  Francesca Potenza  Vincenzo Sorrentino  Hao Li  Mario Romani  Vera Lemos  Kristina Schoonjans  Nicola Zamboni  Graham Knott  Bernard L Schneider  Johan Auwerx
Institution:1. Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;2. Laboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland;3. Department of Biology, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich (ETHZ), CH-8093, Zurich, Switzerland;4. BioEM Facility, Faculty of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;5. Brain Mind Insitute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
Abstract:
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  • Keywords:aging  fission/fusion  mitochondria  mitochondrial dynamics  mitophagy  proteostasis  protein aggregation diseases  neurodegeneration  RNA binding proteins  ribonucleoprotein granules
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