Involvement of steroids in anti-inflammatory effects of peripheral benzodiazepine receptor ligands |
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Authors: | Farges Roseli C Torres Sandra R Ferrara Pascual Ribeiro-do-Valle Rosa M |
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Affiliation: | Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Rua Ferreira Lima, 82, Florianópolis, SC, 88015-420, Brazil. roseli.farges@wanadoo.fr |
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Abstract: | Mouse paw oedema induced by carrageenan is used to determine if glucocorticoids are involved in the anti-inflammatory effects of peripheral benzodiazepine receptor ligands. The anti-inflammatory responses elicited by i.p. treatment with 1-(2-chlorophenyl)-N-methyl-N (1-methyl-propyl)-3-isoquinoline carboxamide (PK11195) and 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2-H-1, 4-benzodiazepin-2 (Ro5-4864) were reversed by aminoglutethimide, an inhibitor of steroidal synthesis. Intraplantar injection into the ipsilateral paw of Ro5-4864, but not PK11195, inhibited the formation of paw oedema and this effect was reversed by aminoglutethimide. These results suggest that glucocorticoids are involved in the systemic and local anti-inflammatory effects of Ro5-4864 and only in the systemic response to PK11195. |
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Keywords: | Benzodiazepine receptor Peripheral Paw oedema Glucocorticoids |
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