Effects of beta-amyloid on proliferation and morphology of yeast Saccharomyces cerevisiae |
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Authors: | A Chaciska W Wony M Boguta A Misicka M Brzyska and D Elbaum |
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Institution: | (1) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland;(2) Nencki Institute of Experimental Biology, Warsaw, Poland;(3) Department of Chemistry, Warsaw University, Warsaw, Poland |
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Abstract: | Deposition of beta-amyloid peptide (1–42) ( AP) in the brain is an early event linked with pathogenesis of cell injury and death in Alzheimer disease. Previous studies have demonstrated that AP induces cytotoxicity in several types of human cells. Surprisingly, the peptide was found not only to be non toxic for yeast cells, but to stimulate growth of yeast culture. The results are consistent with AP binding to yeast cell as illustrated by binding isotherms with theapparent dissociation constant of 8 × 10-7 M and Bmax of 4.7 × 104 molecules/cell. |
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Keywords: | beta-amyloid peptide binding growth stimulation yeast Saccharomyces cerevisiae |
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