1. Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China;2. State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Chinese Academy of Science (CAS), Yangling, Shaanxi 712100, PR China
Abstract:
From the culture of an endophyte Chaetomium globosum found in Ginkgo biloba, twelve metabolites, including three diketopiperazines, two cytochalasins, two sterols, two simple phenolic compounds, one complex aromatic compound, a nonprotein amino acid and a linear triterpene were isolated. Of them, eight compounds are first reported for the genus Chaetomium. Gliotoxin (8) has good antifungal activity against plant pathogenic fungi.
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Highlights? Twelve compounds were isolated from an endophyte C. globosum harboring inside G. biloba leaves. ? Eight compounds are new for the genus Chaetomium. ? Gliotoxin (8) possessed good antifungal activity against some phytopathogenic fungi.
