Role of WASP in cell polarity and podosome dynamics of myeloid cells |
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| Authors: | James Monypenny Hsiu-Chuan Chou Inmaculada Bañón-Rodríguez Adrian J Thrasher Inés M Antón Gareth E Jones Yolanda Calle |
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| Institution: | 1. Randall Division of Cell & Molecular Biophysics, King''s College London, London SE1 1UL, UK;2. Cellular and Molecular Department, Centro Nacional de Biotecnología—CSIC, Madrid 28049, Spain;3. Molecular Immunology Unit, Institute of Child Health, University College London, London WC1, UK;4. Department of Haemato-oncology, King''s College London, London SE5 9NU, UK |
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| Abstract: | The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current article we discuss the role of various factors in initiation and stability of podosomes and the roles of the Wiskott Aldrich Syndrome Protein (WASP) in this process. We discuss recent data indicating that in a cellular context WASP is crucial not only for localised actin polymerisation at the leading edge and in podosome cores but also for coordination of integrin clustering and activation during podosome formation and disassembly. |
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