ATP-gamma-S (adenosine 5'-O-(3-thiotriphosphate] microinjection increases progesterone-stimulated histone kinase activity in Xenopus oocytes |
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Authors: | J C Labbé A Picard M Dorée |
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Affiliation: | INSERM U.249 and CNRS-CRBM, Montpellier, France. |
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Abstract: | Progesterone stimulates the activity of a potent Ca2+- and cyclic nucleotide-independent histone kinase in Xenopus oocytes. Microinjection of ATP-gamma-S during the course of meiotic maturation or after the oocytes had arrested at second meiotic metaphase resulted in a further increase of this histone kinase activity in progesterone-stimulated oocytes. ATP-gamma-S microinjection also increased and stabilized the activity of the maturation-promoting factor. The possible mechanism of ATP-gamma-S action is discussed. |
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