Acute exposure of rhesus monkeys to DDT: Effect on carbohydrate metabolism |
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Authors: | P.K. Dudeja S.N. Sanyal N. Agarwal T.N. Rao D. Subrahmanyam G.K. Khuller |
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Affiliation: | Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012 India |
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Abstract: | Four furocoumarins, two having a linear molecule, psoralen and 8-methylpsoralen and two having an angular molecule, angelicin and 4,5′-dimethylangelicin were tested for mutagenesis in Escherichia coli B wild type and in various strains deficient in known repair systems. The results indicate that both monoadducts and crosslinks are mutagenic. The mutagenic efficiency of the furocourmarins ranks in the following order 8-methylpsoralen > psoralen > angelicin > 4,5′-dimethylangelicin. |
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