Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin |
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Authors: | Amornrat Jearnpipatkul Bhinyo Panijpan |
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Affiliation: | Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok Thailand |
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Abstract: | Chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from Plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin IX and hematoporphyrin. These drugs also compete with one another in their binding to hemin. It is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite. |
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Keywords: | To whom correspondence should be sent |
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