An electron spin resonance study of the novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazine |
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Authors: | B Kalyanaraman R P Mason K Sivarajah |
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Affiliation: | Department of Molecular Biology, The Wellcome Research Laboratories 3030 Cornwallis Road, Research Triangle Park, North Carolina 27709, U.S.A. |
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Abstract: | Thrombin stimulation of [32P]-prelabeled platelets induces a rapid decrease of the radioactivity from phosphatidylinositol-4,5-bisphosphate. No significant change is observed in phosphatidylinositol-4-monophosphate. The initial, thrombin-induced decrease of phosphatidylinositol-4,5-bisphosphate is not inhibited by cytochalasin D or by compounds that interfere with the mobilization of Ca2+ such as 8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate, the calmodulin-antagonist, trifluoperazine, prostacyclin and cyclic AMP. Our information indicates that the rapid loss of phosphatidylinositol-4,5-bisphosphate is linked to receptor activation and insensitive to Ca2+-mobilization. |
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Keywords: | To whom reprints requests and correspondence should be addressed. |
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