Production of actinomycin D with immobilizedStreptomyces parvullus under nitrogen and carbon starvation conditions |
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| Authors: | Mina Dalili Pao C. Chau |
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| Affiliation: | (1) North Carolina State University, USA;(2) Department of AMES (Chemical Engineering), University of California, 92093 San Diego, California |
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| Abstract: | Summary The productivity of actinomycin D withStreptomyces parvullus could be enhanced with calcium alginate immobilized cells and a synthetic starvation medium in a continuous air-lift bioreactor with moderately low dilution rate. In addition, the cell mass must be cycled periodically between the growth and starvation media to maintain long-term antibiotic production. |
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