Effects of ethanol ingestion on sperm monosaccharides and fertility |
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Authors: | Srikanth V Aruldhas M M Srinivasan N Govindarajulu P Balasubramanian K |
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Institution: | Department of Endocrinology, Dr. ALM, Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. |
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Abstract: | Chronic alcohol abuse is often associated with reproductive disorders. Sperm monosaccharides play an indispensable role in sperm-egg interactions and fertilization. Ethanol (3 g/kg body weight as 25%, v/v) was given by gastric intubation twice daily for 30 days while in another group, rats which had been treated with ethanol were withdrawn from treatment for a further period of 30 days, in order to assess the reversibility of the ethanol-induced effects. Epididymal ethanol content, sperm monosaccharides and the fertility of ethanol treated and ethanol withdrawn rats were assessed. Ethanol ingestion caused a significant decrease in sperm monosaccharides suggesting defective glycosylation of sperm surface proteins. Sperm monosaccharides and fertility were returned to normal following the withdrawal of ethanol. Ethanol-induced changes in sperm monosaccharides may be one of the reasons for the reduced fertility of ethanol treated rats. |
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